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Vicasinabin

CAT: 0804-HY-145604-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145604-01Size:1 mg
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Description
Vicasinabin (RG7774) is an orally active, selective, and full CB2R agonist, with EC50 values of 2.81 nM and 2.60 nM for human CB2R and mouse CB2R, respectively. Vicasinabin inhibits inflammation, reduces leukocyte adhesion and decreases vascular permeability by selectively activating CB2R. Vicasinabin can be used in the researches for diabetic retinopathy, uveitis and laser-induced choroidal neovascularization[1][2].
CAS Number
1433361-02-4
Product Name Alternative
RG7774
UNSPSC
12352005
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vicasinabin.html
Purity
98.37
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(C)(C)C1=NC(N2CC[C@@H](C2)O)=C(N=N3)C(N3CC4=NN=NN4C)=N1
Molecular Formula
C15H22N10O
Molecular Weight
358.40
References & Citations
[1]Jean-Michel Adam, et al. Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives. Patent US20130116236A1.|[2]Grether U, et al. RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models. Front Pharmacol. 2024 Jul 12;15:1426446.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CB2

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CatalogName
BA5214-5Vicasinabin

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