Nurr1 agonist 9

• UNSPSC Description:

  Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC50 of 0.090 µM and a Kd of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC50=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC50=0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable[1].

• Target Antigen:

  Nuclear Hormone Receptor 4A/NR4A

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nurr1-agonist-9.html

• Smiles:

  CC1=C(NC(C2=CC=C(C3=CC=C(N(C)C)C=C3)O2)=O)N(C=CC=C4Cl)C4=N1

• Molecular Weight:

  394.85

• References & Citations:

  [1]Sai M, et al., Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing. Commun Chem. 2024 Jun 29;7(1):149.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported