Oxcarbazepine-d4

Oxcarbazepine-d4

• CAS Number: 1020719-71-4
• UNSPSC Description: Oxcarbazepine-d4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].
• Target Antigen: Apoptosis; Isotope-Labeled Compounds; Sodium Channel
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Membrane Transporter/Ion Channel;Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: C(N)(=O)N1C=2C(C(=O)CC=3C1=C(C(=C(C3[2H])[2H])[2H])[2H])=CC=CC2
• Molecular Weight: 256.29
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Ashley M Thomas, et al. Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?J Pain. 2018 Jan;19(1):1-9.|[3]Ching-Yi Lee,et al. The effects of antiepileptic drugs on the growth of glioblastoma cell lines. J Neurooncol. 2016 May;127(3):445-53.|[4]M Schmutz, et al. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Epilepsia. 1994;35 Suppl 5:S47-50.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported