Hydroxyacid Oxidase-1/HAO-1, Human Recombinant
CAT:
26-P1474-10
Size:
10 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: Yes
Hydroxyacid Oxidase-1/HAO-1, Human Recombinant
- Description: Glycolate oxidase is a member of the superfamily of the αhydroxy acid oxidases (HAO), enzymes that are present in both plants and animals. It catalyzes the FMNmediated oxidation of glycolate to glyoxylate and glyoxylate to oxalate with reduction of oxygen to hydrogen peroxide. The cofactor, FMN, is tightly bound but not covalently linked to the protein. In humans and other vertebrates, HAOs are found primarily in the peroxisomes of liver, kidney, and pancreas. Three HAOs have been identified in humans. HAO1 is most highly expressed in liver and pancreas and is most active on glycolate, twocarbon substrates. Glycolate oxidase oxidizes glycolic acid to glyoxylate, and can also oxidize glyoxylate into oxalate. These reactions are central to the toxicity of ethylene glycol poisoning. Recently, HAO has been identified as a major contributor to hyperoxaluria, a disorder in which large deposits of calcium oxalate form kidney stones.
- CAS Number: 9000-83-3
- Shipping Conditions: Dry Ice
- Storage Conditions: -80°C
- Shelf Life: 12 months