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R-7050

CAT: 0026-B3063-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B3063-5Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R-7050 is a cell-permeable inhibitor of signaling through the TNFα receptor (TNFαR) complex. It blocks the formation of signal-initiating complexes that consist of TNFα receptor (TNFαR) I, TNFαR associated death domain protein (TRADD) and receptor interacting protein 1 (RIP1) through inhibition of ligand-induced receptor endocytosis. It inhibits TNFα-induced intercellular adhesion molecule 1 (ICAM-1) expression with an EC₅₀ of 0.631 µM. It (6-12 mg/kg) improves neurovascular injury after intracerebral hemorrhage in mice.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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