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S1RA (E-52862)

CAT: 0026-B3048-1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0026-B3048-1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S1RA is a highly selective sigma-1 (σ1) receptor antagonist. It shows high affinity for σ1 receptors with Ki values of 17 nM and 23.5 nM for human and guinea pig σ1 receptors respectively but no significant affinity for the σ2 receptors with Ki values of 1000 nM and 9300 nM for guinea pig and rat σ2 receptors respectively. It shows moderate affinity (Ki = 328 nM) and antagonistic activity with low potency at the human 5-HT2B receptor. S1RA inhibits neuropathic pain in formalin-induced nociception and capsaicin-induced mechanical hypersensitivity in mice. Sigma receptor modulators may show activity against SARS-CoV-2 as sigma receptors interact with SARS-CoV-2 proteins Nsp6 and Orf9c.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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Alternative Products

CatalogName
BE177449-01E 52862 (S1RA)
A12504-5S1RA (E-52862) 5mg
A12504-50S1RA (E-52862) 50mg
A12504-1S1RA (E-52862) 1mg
A12504-25S1RA (E-52862) 25mg
A12504-10S1RA (E-52862) 10mg
A12504-10mM-DS1RA (E-52862) 10mM * 1mL in DMSO
526719E-52862 HCl
abx282968-01S1RA
571887LUN 52862

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