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Cenicriviroc

CAT: 0026-B3026-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-B3026-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cenicriviroc is a potent inhibitor of C-C chemokine receptors CCR5 and CCR2. It is an orally bioavailable derivative of TAK-779 with potent anti-HIV-1 activity. It blocks the binding of MIP-1α and MIP-1β to CCR5 with an IC₅₀ of 2.3 nM. It inhibits the binding of MCP-1 to CCR2b with an IC₅₀ of 5.9 nM. It inhibits the replication of R5X4HIV-1 in U87.CD4.CCR5 cells at a concentration of 100 nM. It shows potent anti-inflammatory and antifibrotic activity in animal models of fibrosis.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36months

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