Ro 08-2750

CAT: 0026-B3017-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B3017-5Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ro 08-2750 is an antagonist of nerve growth factor (NGF). It binds to the NGF dimer (Kd ~ 1 μM) and probably induces a change in its conformation such that NGF cannot bind to neurotrophin receptor p75(NTR). It inhibits NGF-induced cell death of SK-N-MC cells. It reverses NGF-induced decrease in β-catenin mRNA expression and decrease in migration of SKOV3 and OVCAR-3 ovarian cancer cells at a concentration 10 μM.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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