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Allitinib

CAT: 0026-B3002-1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0026-B3002-1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Allitinib is a novel anilino-quinazoline compound that inhibits ErbB tyrosine kinases: epidermal growth factor receptor (EGFR) and ErbB2. It inhibits EGFR and ErbB2 with IC₅₀ values of 0.5 nM and 3 nM in cell-free assays. It inhibits the phosphorylation of EGFR and ErbB2 and downstream signaling in human cancer cells. It potently inhibits cell lines expressing high levels of ErbB2 such as Calu-3 lung adenocarcinoma and BT474 breast cancer cells with IC₅₀ values of 0.23 μM and 0.97 μM respectively. It inhibits tumor growth in the SK-OV-3 xenograft model.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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