Branebrutinib

CAT: 0026-B2998-5Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0026-B2998-5Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Branebrutinib is a potent covalent, irreversible inhibitor of Bruton's tyrosine kinase (BTK). BTK is a non-receptor tyrosine kinase. It is a member of the Tec family of kinases and is essential for B cell receptor (BCR) mediated signaling. Branebrutinib inhibits BTK with IC₅₀ values of 0.1 nM, 0.9 nM, 1.5 nM and 5 nM for BTK, TEC, BMX and TXK respectively. It inactivates BTK in the human whole blood assay rapidly at a rate of 3.5 × 10−4 nM−1min-1. Branebrutinib inhibits signaling and functional end points, including calcium flux (IC₅₀ = 7 nM), production of cytokines, proliferation, and surface expression of the costimulatory molecule CD86 (IC₅₀ values < 1 nM) in B cells stimulated through the B cell receptor.

Shipping Conditions

Storage Conditions

-20ºC

Shelf Life

36 months

Alternative Products

Catalog	Name
GTR19168463-01	Branebrutinib
A20043-5	Branebrutinib 5mg
A20043-100	Branebrutinib 100mg
A20043-200	Branebrutinib 200mg
A20043-50	Branebrutinib 50mg
A20043-2	Branebrutinib 2mg
A20043-500	Branebrutinib 500mg
A20043-25	Branebrutinib 25mg
A20043-10	Branebrutinib 10mg
A20043-1	Branebrutinib 1mg

Branebrutinib

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