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A-839977

CAT: 0026-B2973-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B2973-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-839977 is a potent antagonist of the purinergic receptor P2X subtype 7 (P2X7). A-839977 potently blocks BzATP-induced calcium influx at recombinant human, rat and mouse P2X7 receptors with IC₅₀ values of 20 nM, 42 nM and 150 nM respectively. It also potently blocks agonist-induced YO-PRO uptake and IL-1β release from differentiated human THP-1 cells. It shows antihyperalgesic and antinociceptive effects in animal models of inflammatory pain.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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