NSC-617145

CAT: 0026-B2664-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B2664-5Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC- 617145 is an inhibitor of Werner syndrome helicase (WRN) (IC₅₀ = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only displaying 7% inhibition of RECQ1 at a concentration of 5 µM. It acts synergistically with Mitomycin C (Cat. No. 2713) to induce double-strand breaks and chromosomal abnormalities in vitro.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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