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Pirfenidone

CAT: 0026-B2660-50Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0026-B2660-50Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pirfenidone is a small molecule antifibrotic agent. Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin. In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis. Pirfenidone also displays anti-inflammatory and antioxidant properties.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

Alternative Products

CatalogName
B2288-5.1Pirfenidone

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