Importazole

CAT: 0026-B2958-5Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0026-B2958-5Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Importazole is a 2,4-diaminoquinazoline that inhibits the function of transport receptor importin-β, likely by altering its interaction with RanGTP. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells with an IC₅₀ of 15 μM, which is reversible upon importazole washout. Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and NF-κB in multiple myeloma cells. It induces apoptosis and inhibits growth of multiple myeloma cell lines with IC₅₀ values of 4.4 μM and 4.8 μM, respectively. It also induces defects in astral MT dynamics and misoriented spindles.

Shipping Conditions

Storage Conditions

-20ºC

Shelf Life

36 months

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Catalog	Name
A4643-50	Importazole

Importazole

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