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Urolithin A

CAT: 0400-SIH-610-25MGSize: 25 mgDry Ice: NoHazardous: No
CAT#: SIH-610-25MGSize: 25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Urolithin A (UA) is a microbial metabolite of dietary ellagitannins produced in the gut (1). It has been shown to induce mitophagy and prolong lifespan in C. elegans and increase muscle function in rodents (2). It promotes mitophagy and suppresses NLRP3 inflammasome activation in LPS-induced BV2 microglial cells and in an MPTP-induced Parkinson’s disease model (3). The pro-mitophagy activity of Urolitin A may be beneficial in Alzheimer’s disease (4). Ex vivo UA-treated T cells display improved anti-tumor function (5).
Description
Mitophagy inducer
CAS Number
1143-70-0
Product Name Alternative
3,8-Dihydroxy-6H-dibenzo[b, d]pyran-6-one; or 2',7-Dihydroxy-3,4-benzocoumarin
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Alzheimer's Disease | Cancer | Parkinson's Disease
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
Pale-yellow powder
Solubility
May be dissolved in DMSO (50 mg/ml)
Molecular Formula
C13H8O4
Molecular Weight
228.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1.Gonzalez-Barrio R., et al. (2011) J. Agric. Food. Chem. 59:1152 2.Ryu D., et al. 2016 Nat. Med. 22:879 3.Qiu J., et al. 2022 Neuropharmacology 207:108963 4.Jayatunga D.P.W., et al. 2021 Nutrients. 13:3744 5.Denk D., et al. 2022 Immunity. 55:2059

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