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SMase Activation Associated Factor

CAT: 0579-X2289BSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0579-X2289BSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Novel adaptor protein which mediates the activation of sphingomyelinase by receptors such as tumor necrosis factor receptor type 1 and CD40 and subsequent apoptosis in cardiomyocytes. Inhibition of this factor may provide a novel intervention point for reducing ischemia/reperfusion injury.
Synonyms
nSMAF, Neutral sphingomyelinase (N-SMase) activation associated factor
UniProt
Q8IW26
Species Reactivity
Human
Conjugation
Unconjugated
Type
Blocking Peptide
Applications
WB
Assay Principle
For use with FXBW7 polyclonal antibodies (Cat. No. X2314P , X2336P).
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. O’Brien, N.W., et al. 'Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death.' Circ Res. 2003 Apr 4;92(6):589-91. 2. Segui, B., et al. 'CD40 Signals apoptosis through FAN-regulated activation of the sphinogmyelin-ceramide pathway.' J Biol Chem. 1999; 274: 37251–37258 3. Adam-Klages, S., et al. 'FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase.' Cell. 1996; 86: 937–947. 4. Segui, B., et al. 'Involvement of FAN in TNF-induced apoptosis.' J Clin Invest. 2001; 108: 143–151.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB

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