Sulfosuccinimidyl oleate

• UNSPSC Description:

  Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1][2].

• Target Antigen:

  Mitophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Sulfosuccinimidyl_oleate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O)=O

• Molecular Weight:

  459.60

• References & Citations:

  [1]Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237.|[2]Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51.BMC Cancer. 2023 Apr 21;23(1):367.|Cancer Lett. 2023 Nov 25, 216511.|Cell Immunol. 11 January 2022, 104475.|Cell Rep. 2024 Jul 9;43(7):114465.|CNS Neurosci Ther. 2023 May 8.|Food Res Int. 2023 Nov, 173, 113328.|Food Sci Nutr. 2023 Nov 22.|Front Pharmacol. 2020 Dec 16;11:593832.|Int J Biol Macromol. 2023 Oct 12:127324.|Int J Mol Sci. 2023 Aug 31, 24(17), 13516.|SSRN. 2023 Aug 30.|Toxicol Sci. 2022 Dec 19;kfac133.|Toxins. 2021, 13(11), 802.|Cell Death Dis. 2024 Aug 26;15(8):623.|Cell Rep Med. 2024 May 29:101592.|Cell Rep. 2024 Oct 19;43(11):114881.|Heliyon. 2024 Nov 28;10(23):e40806.|J Agric Food Chem. 2024 Jul 10.|J Exp Med. 2023 Mar 6;220(3):e20221316.|J Transl Med. 2023 Feb 6;21(1):89.|Research Square Preprint. 2023 Oct 11.|Research Square Print. December 29th, 2022.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  135661-44-8