Jasplakinolide

• UNSPSC Description:

  Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].

• Target Antigen:

  Arp2/3 Complex; Fungal

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Cytoskeleton

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/jasplakinolide.html

• Purity:

  99.50

• Solubility:

  DMSO : 10 mg/mL (ultrasonic;warming)

• Smiles:

  BrC1=C(C2=CC=CC=C2N1)C[C@@H](N(C([C@@H](NC([C@H](C/C(C)=C/[C@@H]3C)C)=O)C)=O)C)C(N[C@](C(C=C4)=CC=C4O)([H])CC(O[C@H](C3)C)=O)=O

• Molecular Weight:

  709.67

• References & Citations:

  [1]Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269(21):14869-71.|[2]Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  102396-24-7