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Jasplakinolide

CAT: 0804-HY-P0027-01Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0027-01Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].
CAS Number
102396-24-7
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Arp2/3 Complex; Fungal
Type
Natural Products
Related Pathways
Anti-infection; Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/jasplakinolide.html
Purity
99.56
Solubility
DMSO : ≥ 2mg/mL
Smiles
BrC1=C(C2=CC=CC=C2N1)C[C@@H](N(C([C@@H](NC([C@H](C/C(C)=C/[C@@H]3C)C)=O)C)=O)C)C(N[C@](C(C=C4)=CC=C4O)([H])CC(O[C@H](C3)C)=O)=O
Molecular Formula
C36H45BrN4O6
Molecular Weight
709.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269 (21) :14869-71.|[2]Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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