Thalidomide-O-amido-C4-NH2 (TFA)

Thalidomide-O-amido-C4-NH2 (TFA)

• CAS Number: 1799711-25-3
• UNSPSC Description: Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_16.html
• Purity: 99.92
• Solubility: DMSO : 42.86 mg/mL (ultrasonic)
• Smiles: NCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O.FC(F)(F)C(O)=O
• Molecular Weight: 516.42
• References & Citations: [1]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2017 Mar 24.|[2]James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported