Seltorexant

CAT: 0804-HY-109012-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-109012-01Size:5 mg
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Description
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R) . Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].
CAS Number
[1293281-49-8]
Product Name Alternative
JNJ-42847922
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/seltorexant.html
Concentration
10mM
Purity
99.86
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N1CC(CN(C2=NC(C)=CC(C)=N2)C3)C3C1)C4=C(N5N=CC=N5)C=CC=C4F
Molecular Formula
C21H22FN7O
Molecular Weight
407.44
Precautions
H301, H311, H331
References & Citations
[1]Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354 (3) :471-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
OX2 Receptor
Citation 01
Bioorg Chem. 2022 Jun;123:105779.|Int J Neuropsychopharmacol. 2025 Aug 1;28 (8) :pyaf047.|Int J Neuropsychopharmacol. 2025 Aug 1;28 (8) :pyaf047.

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