Triptophenolide

• Description :

  Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value: Target: In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1]. In vivo:

• Product Name Alternative :

  Hypolide; (+) -Triptophenolide

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Androgen Receptor

• Type :

  Natural Products

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/Triptophenolide.html

• Purity :

  99.98

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C(CC[C@]2(C)C3=C(CC[C@]24[H])C(O)=C(C(C)C)C=C3)=C4CO1

• Molecular Formula :

  C20H24O3

• Molecular Weight :

  312.40

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]XU bin, et al. Study on polarographic catalytic wave of triptophenolide. Chinese Journal of Analysis Laboratory, 2005-04|[2]Yang Jun, et al. Studies on Antiinflammatory and Immune Effects of Triptophenolide. Chinese Traditional and Herbal Drugs, 1995-01

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [74285-86-2]