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Halociline

CAT: 0804-HY-N12726Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N12726Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities[1][2].
CAS Number
2977255-36-8
UNSPSC
12352005
Target
MMP; p38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/halociline.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C=C(C=C1C(C(O)C)C)O)N
Molecular Formula
C11H17NO2
Molecular Weight
195.26
References & Citations
[1]Mohamed M M Abdel Razek, et al. A New Phenolic Alkaloid from Halocnemum strobilaceum Endophytes: Antimicrobial, Antioxidant and Biofilm Inhibitory Activities. Chem Biodivers. 2020 Oct;17 (10) :e2000496.|[2]Xiangru Zha, et al. Network pharmacology, molecular docking, and molecular dynamics simulation analysis reveal the molecular mechanism of halociline against gastric cancer. Mol Divers. 2024 Mar 19.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MMP-9; p38 MAPK

Alternative Products

CatalogName
GTR19233644-01Halociline

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