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DiaPep277

CAT: 0804-HY-105063-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105063-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes[1][2].
CAS Number
179822-83-4
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/diapep277.html
Purity
99.44
Solubility
DMSO : 12.5 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC(C)C)C(NCC(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CCC1)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N2[C@@H](CCC2)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N
Molecular Formula
C106H180N28O34
Molecular Weight
2390.73
References & Citations
[1]Eldor R, et al. Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results. Diabetes Metab Res Rev. 2009 May;25 (4) :316-20.|[2]Elias D, et al. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci U S A. 1991 Apr 15;88 (8) :3088-91.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
Phase 3

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