GLUT4-IN-2

• Description :

  GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with IC50s of 11.4 μM and 6.8 μM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; GLUT

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/glut4-in-2.html

• Purity :

  99.17

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  O=C(NC1=NC2=CC=CC=C2S1)CN(C/3=O)C(SC3=C\C4=CC=CO4)=O

• Molecular Formula :

  C17H11N3O4S2

• Molecular Weight :

  385.42

• References & Citations :

  [1]Tilekar K, et al. Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential. Eur J Med Chem. 2020 Sep 15;202:112603.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  GLUT1; GLUT4

• CAS Number :

  [2454113-83-6]