TP0472993

CAT: 0804-HY-151810-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-151810-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 has potential for the research of renal diseases[1].

CAS Number

2126874-77-7

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tp0472993.html

Concentration

10mM

Purity

98.22

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC(N1CCC(CC1)COC2=CC=C(N=C2)C3=CC=NN3)=O

Molecular Formula

C16H20N4O2

Molecular Weight

300.36

References & Citations

[1]Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65 (21) :14599-14613.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP4

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TP0472993

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