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Amyloid Precursor Protein Antibody

CAT: 0013-GTR18177980Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18177980Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal antibody to Amyloid Precursor Protein (APP)
UniProt
P05067
Reactivity
Human, Mouse, Rat
Immunogen
Full length human recombinant protein of human APP (NP_000475) produced in HEK23T cell.
Target
Amyloid Precursor Protein
Clonality
Monoclonal
Clone
BQVK8H33
Conjugation
Unconjugated
Field of Research
Neuroscience
Dilution
WB 1:2000, IHC 1:150, IF 1:100
Molecular Weight
85.1 kDa
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process.
Tested Applications
IF, IHC, WB
NCBI Accession Number
NM_000484
Host or Source
Mouse
Isotype
IgG2a

UniProtKB · P05067

Amyloid-beta precursor protein

A4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05067
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
APP
EC number
—
Processing
Precursor
Secondary accessions
B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q6GSC0, Q8WZ99, Q9BT38, Q9UC33, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseAmyloidosisDisease variantNeurodegeneration

Cellular component

AmyloidCell membraneCell projectionCoated pitCytoplasmCytoplasmic vesicleEndoplasmic reticulumEndosomeGolgi apparatusMembraneNucleusSecreted

Biological process

ApoptosisCell adhesionEndocytosisNotch signaling pathway

Ligand

CopperIronMetal-bindingZinc

PTM

Disulfide bondGlycoproteinIsopeptide bondOxidationPhosphoproteinProteoglycanSulfationUbl conjugation

Molecular function

Heparin-bindingProtease inhibitorSerine protease inhibitor

Domain

SignalTransmembraneTransmembrane helix

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