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Ro 31-7837

CAT: 0804-HY-121917Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121917Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APTO-253 (LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4 (KLF4) tumor suppressor. APTO-253 hydrochloride exhibits antiarthritic activity.
CAS Number
120280-33-3
UNSPSC
12352005
Target
Apoptosis; c-Myc
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ro-31-7837.html
Smiles
N#CC1=CC=C2C(C(C3=[N+]([O-])C=CC=C3)CC(C)(C)O2)=C1
Molecular Formula
C17H16N2O2
Molecular Weight
280.32
References & Citations
[1]Simultaneous determination of a potassium channel opener and its metabolite in rat plasma with column-switching liquid chromatography using atmospheric pressure chemical ionisation
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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