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M47

CAT: 0804-HY-148764-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148764-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M47 is a molecular glue that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1].
CAS Number
890808-56-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Cryptochrome; Molecular Glues
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m47.html
Purity
99.96
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(N1C2=C(CC1)C=CC=C2)C(OC3=CC=C4OC(C)(C5)C6=CC=C(C=C6)Cl)=C(C)C3=C4C5=O
Molecular Formula
C28H22ClNO4
Molecular Weight
471.93
Precautions
H315, H319, H335
References & Citations
[1]Gul S, et, al. Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice. Nat Commun. 2022 Nov 8;13 (1) :6742.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CRY1

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