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Facinicline

CAT: 0804-HY-108057Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108057Size:1 Each
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Description
Facinicline (RG3487) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM[1].
CAS Number
677306-35-3
Product Name Alternative
RG3487 (free base)
UNSPSC
12352005
Target
5-HT Receptor; nAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/facinicline.html
Smiles
O=C(C1=NNC2=C1C=CC=C2)N[C@@H]3CN4CCC3CC4
Molecular Formula
C15H18N4O
Molecular Weight
270.33
References & Citations
[1]Tanya L Wallace, et al. RG3487, a Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents. J Pharmacol Exp Ther. 2011 Jan;336 (1) :242-53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Facinicline
CAS Number677306-35-3
PubChem CID9970357
IUPAC NameN-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-1H-indazole-3-carboxamide
Molecular FormulaC15H18N4O
Molecular Weight270.33
XLogP1.8
Topological Polar Surface Area61
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity380
SMILES
C1CN2CCC1[C@@H](C2)NC(=O)C3=NNC4=CC=CC=C43
InChI
InChI=1S/C15H18N4O/c20-15(14-11-3-1-2-4-12(11)17-18-14)16-13-9-19-7-5-10(13)6-8-19/h1-4,10,13H,5-9H2,(H,16,20)(H,17,18)/t13-/m1/s1
InChIKey
TXCYUSKWBHUVEP-CYBMUJFWSA-N
Chemical Structure
2D Structure
2D structure of Facinicline
CAS: 677306-35-3
CID: 9970357
Formula: C15H18N4O
MW: 270.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight270.33
XLogP31.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass270.14806121
Monoisotopic Mass270.14806121
Topological Polar Surface Area61 Ų
Heavy Atom Count20
Formal Charge0
Complexity380
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3616502-01Facinicline hydrochloride
GTR19195079-01Facinicline (free base)

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