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YF438

CAT: 0804-HY-164550Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164550Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YF438 is an HDAC inhibitor with effective anticancer activity both in vitro and in vivo. YF438 inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2-MDMX, and promoting the degradation of MDM2[1].
CAS Number
2247210-09-7
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yf438.html
Smiles
O=C(CCCCCC(NO)=O)N(CC1=NOC(C2=CC=CC=C2)=N1)C3=CC=C(OC)C=C3
Molecular Formula
C23H26N4O5
Molecular Weight
438.48
References & Citations
[1]Shan P, et al. Alteration of MDM2 by the Small Molecule YF438 Exerts Antitumor Effects in Triple-Negative Breast Cancer. Cancer Res. 2021 Aug 1;81 (15) :4027-4040.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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