Pictilisib

CAT: 0804-HY-50094-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-50094-01Size:10 mg

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Description

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with an IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold) .

CAS Number

957054-30-7

Product Name Alternative

GDC-0941

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; PI3K

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GDC-0941.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CS(N1CCN(CC2=CC3=C(C(N4CCOCC4)=NC(C5=CC=CC6=C5C=NN6)=N3)S2)CC1)(=O)=O

Molecular Formula

C23H27N7O3S2

Molecular Weight

513.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Wallin JJ, et al. GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of RP-56976 in human breast cancer models by increasing cell death in vitro and in vivo.Clin Cancer Res. 2012 Jul 15;18 (14) :3901-11. Epub 2012 May 14.|[2]Wullschleger S, et al. Quantitative MRI establishes the efficacy of PI3K inhibitor (GDC-0941) multi-treatments in PTEN-deficient mice lymphoma.Anticancer Res. 2012 Feb;32 (2) :415-20.|[3]Zou ZQ, et al. The novel dual PI3K/mTOR inhibitor GDC-0941 synergizes with the MEK inhibitor U0126 in non-small cell lung cancer cells.Mol Med Report. 2012 Feb;5 (2) :503-8.|[4]Burrows N, et al. GDC-0941 inhibits metastatic characteristics of thyroid carcinomas by targeting both the phosphoinositide-3 kinase (PI3K) and hypoxia-inducible factor-1α (HIF-1α) pathways.J Clin Endocrinol Metab. 2011 Dec;96 (12) :E1934-43. Epub 2011 Oct|[5]Folkes AJ, et al. The identification of 2- (1H-indazol-4-yl) -6- (4-methanesulfonyl-piperazin-1-ylmethyl) -4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer . J Med Chem. 2008 Sep 25;51 (18) :5522-32.|[6]Ni J, et al. Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2012 May;2 (5) :425-33.|[7]Cheng H, et al. A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. Cancer Res. 2014 Jan 1;74 (1) :15-23.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

Citation 01

Chemical Information

Pictilisib

Pictrelisib is a sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is a thienopyrimidine, a member of piperazines, a sulfonamide, a member of indazoles and a member of morpholines.

CAS Number	957054-30-7
PubChem CID	17755052
IUPAC Name	4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
Molecular Formula	C23H27N7O3S2
Molecular Weight	513.6
XLogP	1.6
Topological Polar Surface Area	144
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	5
Heavy Atom Count	35
Formal Charge	0
Complexity	831

SMILES

CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6

InChI

InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)

InChIKey

LHNIIDJUOCFXAP-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 957054-30-7

CID: 17755052

Formula: C23H27N7O3S2

MW: 513.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	513.6
XLogP3	1.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	5
Exact Mass	513.16168010
Monoisotopic Mass	513.16168010
Topological Polar Surface Area	144 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	831
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
WGC308040-5mg	Pictilisib
T11381-01	Pictilisib dimethanesulfonate
100958	Pictilisib mesylate
A11444-100	Pictilisib dimethanesulfonate 100mg
A11444-25	Pictilisib dimethanesulfonate 25mg
A11444-5	Pictilisib dimethanesulfonate 5mg
S1065-200mg	Pictilisib (GDC-0941)
201395	GDC-0941 (Pictilisib)
A11444-500	Pictilisib dimethanesulfonate 500mg
A11444-50	Pictilisib dimethanesulfonate 50mg

Pictilisib

Chemical Information

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