Tauroursodeoxycholate

Tauroursodeoxycholate

• CAS Number: 14605-22-2
• UNSPSC Description: Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
• Target Antigen: Apoptosis; Caspase; Endogenous Metabolite; ERK
• Type: Natural Products
• Related Pathways: Apoptosis;MAPK/ERK Pathway;Metabolic Enzyme/Protease;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Tauroursodeoxycholate.html
• Purity: 99.91
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
• Molecular Weight: 499.70
• References & Citations: [1]Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKCα-mediated MKP-1 induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16.|[2]Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345.Adv Sci (Weinh). 2021 Nov;8(21):e2101936.|Am J Pathol. 2023 Oct 31:S0002-9440(23)00412-1.|Anim Cells Syst. 2023 Nov 27.|Appl Biochem Biotechnol. 2024 Mar 25.|Biochem Bioph Res Co. 544 (2021) 44-51.|Biochem Biophys Res Commun. 2024 Apr 25:149972.|Biochem Biophys Res Commun. 2024 Mar 15, 149770.|Biomed Pharmacother. 2019 Dec;120:109475.|Biomed Pharmacother. 2022 May 24;151:113173.|Biomed Pharmacother. 2023 May 22;164:114897.|BMC Mol Cell Biol. 2023 Mar 3;24(1):7.|Br J Pharmacol. 2019 Jul;176(13):2162-2178. |Cancer Med. 2023 Jun 12.|Cancers. 2020 Mar 6;12(3):613.|Cell Biol Toxicol. 2022 Jan 14.|Cell Death Dis. 2020 Apr 24;11(4):279.|Cell Death Dis. 2023 Aug 15;14(8):524.|Cell Rep. 2023 Dec 27;43(1):113591.|Cytokine. 2020 Mar;127:154959.|Departamento de Biotecnología. 2020 Sep.|Diagn Microbiol Infect Dis. 2024 Aug 22;110(4):116500.|Ecotoxicol Environ Saf. 2023 Dec 29:270:115895.|Food Chem Toxicol. 2018 Jul 14;120:253-260.|Front Cell Dev Biol. 2020 May 12;8:269.|Front Pharmacol. 2021 Aug 23;12:708462.|Front Pharmacol. 2022 Sep 16;13:977622.|Gut Microbes. 2024 Jan-Dec;16(1):2392877.|Infect Genet Evol. 2020 Nov;85:104552.|Int Heart J. 2023 Mar 15.|Int Immunopharmacol. 2021 Mar 7;95:107519.|J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1553-1569.|J Cell Mol Med. 2019 Oct;23(10):7029-7042. |J Inflamm. 2023 Nov 1;20(1):36.|J Int Med Res. 2023 May;51(5):3000605231173272.|J Pharm Anal. 2024 Aug 22.|J Steroid Biochem Mol Biol. 2024 Aug 13:106599.|J Trace Elem Med Biol. 2024 Aug 28:86:127512.|Nature. 2024 Dec 18.|Nutr Diabetes. 2024 Sep 13;14(1):75.|Nutr Metab. 2020 Jan 30;17:11.|Pharmacology. 2018 Dec 5;103(1-2):93-100. |Phytomedicine.2023 Sep:118:154971.|PLoS One. 2023 May 18;18(5):e0283943.|Redox Biol. 2023 Aug 25, 102861.|Research Square Preprint. 2023 Oct 23.|Sci Total Environ. 2024 Jul 6:174536.|Sci Total Environ. 2024 Jun 25:946:174299.|Biochem Pharmacol. 2018 May 24;154:278-292.|Biofabrication. 2021 Apr 19.|bioRxiv. 2020 Jun.|Brain Res Bull. 2020 Sep;162:73-83.|Cell Biol Toxicol. 2024 Jan 22;40(1):1.|Cell Prolif. 2021 Sep 28;e13133.|Cell Stress Chaperones. 2022 May;27(3):273-283.|Ecotoxicol Environ Saf. 2022 May 1;236:113508.|FEBS Open Bio. 2020 Oct;10(10):2122-2136.|Fundam Clin Pharmacol. 2018 Aug;32(4):363-377.|Int J Mol Sci. 2023 Jul 20, 24(14), 11692.|Mater Design. 8 November 2021, 110229.|MedComm-Oncology. 2023 Feb 19.|Mol Ther. 2022 Dec 24;S1525-0016(22)00718-3.|Nat Cell Biol. 2023 May;25(5):726-739.|Nutrients. 2021, 13(12), 4343.|Oxid Med Cell Longev. 2022 Aug 31;2022:9004738.|Research Square Preprint. 2023 Oct 16.|Sci Rep. 2017 Aug 30;7(1):9967.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched