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Microgrewiapine A

CAT: 0804-HY-N10132Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N10132Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Microgrewiapine A is an antagonist of nAChR. Microgrewiapine A inhibits hα4β2 and hα3β4 activity with 60% and 70% inhibition, respectively. Microgrewiapine A has selective cytotoxic against HT-29 human colon cancer cells with an IC50 of 6.8 μM[1].
CAS Number
1420777-30-5
UNSPSC
12352005
Target
NAChR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/microgrewiapine-a.html
Solubility
10 mM in DMSO
Smiles
CCCC/C=C/C=C/C=C/[C@H]1N([C@H]([C@@H](CC1)O)C)C
Molecular Formula
C17H29NO
Molecular Weight
263.42
References & Citations
[1]Still PC, et al. Alkaloids from Microcos paniculata with cytotoxic and nicotinic receptor antagonistic activities. J Nat Prod. 2013 Feb 22;76 (2) :243-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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