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Triadimefon

CAT: 0804-HY-123037-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123037-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Triadimefon is an orally active fungicide. Triadimefon significantly reduces the phosphorylation of AKT1 and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory[1][2][3][4][5][6][7].
CAS Number
43121-43-3
UNSPSC
12352005
Hazard Statement
H302, H317, H330, H400, H411
Target
Akt; AMPK; Fungal; PERK
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Infection; Endocrinology; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/triadimefon.html
Purity
98.12
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC(C)(C(C(N1N=CN=C1)OC2=CC=C(C=C2)Cl)=O)C
Molecular Formula
C14H16ClN3O2
Molecular Weight
293.75
Precautions
H302, H317, H330, H400, H411
References & Citations
[1]Kong Z, et al. The fungicide triadimefon affects beer flavor and composition by influencing Saccharomyces cerevisiae metabolism. Sci Rep. 2016 Sep 15;6:33552.|[2]Xu Q, et al. Triadimefon suppresses fetal adrenal gland development after in utero exposure. Toxicology. 2021 Oct;462:152932. |[3]Iyer V V, et al. Effects of Triadimefon on the Metabolism of Cultured Hepatocytes[C]//2010 IEEE International Conference on BioInformatics and BioEngineering. IEEE, 2010: 118-123. |[4]Walker QD, et al. Triadimefon and triadimenol: effects on monoamine uptake and release. Toxicol Appl Pharmacol. 1996 Aug;139 (2) :227-33.|[5]Lin L, et al. Triadimefon increases fetal Leydig cell proliferation but inhibits its differentiation of male fetuses after gestational exposure. Ecotoxicol Environ Saf. 2021 Oct 30;228:112942. |[6]Di Renzo F, et al. Stage-dependent abnormalities induced by the fungicide triadimefon in the mouse. Reprod Toxicol. 2011 Feb;31 (2) :194-9. |[7]Xi J, et al. Suppressive effect of triadimefon, a triazole fungicide, on spatial learning and reference memory in rats. Behav Pharmacol. 2012 Dec;23 (8) :727-34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1

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