Products for Research Use Only
RegisterLogin

ECT2 Antibody [AMM02569G]

CAT: 0882-AMM02569G-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0882-AMM02569G-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Tissue Location: Expressed in lung epithelial cells (at protein level) . Expressed in squamous cell carcinoma, primary non-small cell lung cancer tumors and lung adenocarcinoma
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ECT2 Antibody [AMM02569G].
Synonyms
Protein ECT2, Epithelial cell-transforming sequence 2 oncogene, ECT2
Gene Name
ECT2
Gene ID
1894
UniProt
Q9H8V3
Chromosomal Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cell junction. Cell junction, tight junction. Note=Sequestered within the nucleus during interphase Dispersed throughout the cytoplasm upon breakdown of the nuclear envelope during mitosis. Colocalizes with the centralspindlin complex to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis Colocalized with RhoA at the midbody. Its subcellular localization to tight junction is increased by calcium. Localized predominantly in the cytoplasm of numerous carcinoma cells
Applications
WB
Dilution
WB--1:1000
Function
Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB) -induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A- PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Molecular Weight
103505
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1894
Uniprot URL
https://www.uniprot.org/uniprot/Q9H8V3

Related Products

CatalogName
APG00096GPolyclonal Goat Anti-ECT2 Antibody
APR29137N-01ECT2 Rabbit pAb (APR29137N)
PH30230E1ECT2 (NM_018098) Human Recombinant Protein
AMM04340GMonoclonal ECT2 monoclonal antibody (M01), Clone: 5D4
AMM17770VCFECT2 Mouse Monoclonal Antibody [Clone ID: LBI2D9]
AMM17770VECT2 Mouse Monoclonal Antibody [Clone ID: LBI2D9]
LH10554VECT2 (NM_018098) Human Over-expression Lysate
AMM02509G-01CDKN1B Antibody [AMM02509G]
AMM02559G-01RAB20 Antibody [AMM02559G]
AMM02539G-01RRAS2 Antibody [AMM02539G]

Alternative Products

CatalogName
abx457127-01Protein ECT2 (ECT2) Antibody
GWB-MS591FECT2 Antibody

Popular Products