DMA-135 (hydrochloride)

DMA-135 (hydrochloride)

• CAS Number: 2237925-62-9
• UNSPSC Description: DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1]. DMA-135 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: Enterovirus
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/dma-135-hydrochloride.html
• Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(C1=NC(C#CC2=CC=CC=C2)=C(N(C)C)N=C1N)NC(N)=N.Cl
• Molecular Weight: 359.81
• References & Citations: [1]Davila-Calderon J, Patwardhan NN, Chiu LY, et al. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun. 2020;11(1):4775. Published 2020 Sep 22.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported