HIF1A Antibody (ascites) [APR07748G]

• Background:

  Tissue Location: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland.

• Synonyms:

  Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8, HIF1A, BHLHE78, MOP1, PASD8

• Gene Name:

  HIF1A {ECO:0000303|PubMed:7539918, ECO:0000312|HGNC:HGNC:4910}

• Gene ID:

  3091

• UniProt:

  Q16665

• Chromosomal Location:

  Cytoplasm. Nucleus. Nucleus speckle {ECO:0000250|UniProtKB:Q61221}. Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity) . Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (PubMed:9822602) {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:9822602}

• Applications:

  WB

• Dilution:

  WB--1:100~1000

• Form:

  Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

• Function:

  1129286111566883154650321697362217610843186580462062492822009797988710030125331112928611156688315465032169736221761084320624928220097979887100301253312200979798871001654323610594042102021541059404219528298

• Molecular Weight:

  92670

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HIF1A Antibody (ascites) [APR07748G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=3091

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q16665