CHK1 Antibody (S280) [APR04937G]

• Background:

  Tissue Location: Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon

• Synonyms:

  Serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, CHEK1, CHK1

• Gene Name:

  CHEK1

• Gene ID:

  1111

• UniProt:

  O14757

• Chromosomal Location:

  Nucleus. Chromosome. Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Nuclear export is mediated at least in part by XPO1/CRM1 (PubMed:12676962) . Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B (PubMed:15311285) . Proteolytic cleavage at the C-terminus by SPRTN promotes removal from chromatin (PubMed:31316063)

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  11535615124467741239954414559997149887231531128515665856156500473235793511535615124467741239954414559997149887231531128515665856156500471153561512446774123995441455999714988723153112851566585615650047115356151244677412399544145599971498872315311285156658561565004792785111267658314681206126769251275935119734889145599979278511927851112676583146812061267692512759351197348899278511197348892009042292785111872839315665856106735011565965016511572172967361266017312955071126601731295507118451105173801283131606333108758

• Molecular Weight:

  54434

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CHK1 Antibody (S280) [APR04937G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1111

• Uniprot URL:

  https://www.uniprot.org/uniprot/O14757