ANAPC2 Antibody (C-term) [APR04767G]

• Synonyms:

  Anaphase-promoting complex subunit 2, APC2, Cyclosome subunit 2, ANAPC2, APC2, KIAA1406

• Gene Name:

  ANAPC2

• Gene ID:

  29882

• UniProt:

  Q9UJX6

• Applications:

  WB, IHC-P, IF

• Dilution:

  IF--1:25 IHC-P--1:100~500 WB--1:1000

• Function:

  Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

• Molecular Weight:

  93828

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ANAPC2 Antibody (C-term) [APR04767G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=29882

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UJX6