ROS1 Antibody (C-term) [APR04716G]

• Background:

  Tissue Location: Expressed in brain. Expression is increased in primary gliomas.

• Synonyms:

  Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase, ROS1, MCF3, ROS

• Gene Name:

  ROS1

• Gene ID:

  6098

• UniProt:

  P08922

• Chromosomal Location:

  Cell membrane; Single-pass type I membrane protein

• Applications:

  WB

• Dilution:

  WB--1:1000

• Function:

  Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

• Molecular Weight:

  263915

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ROS1 Antibody (C-term) [APR04716G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=6098

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08922