NSE4A Antibody (N-term) [APR06212G]

• Synonyms:

  Non-structural maintenance of chromosomes element 4 homolog A, NS4EA, Non-SMC element 4 homolog A, NSMCE4A, C10orf86

• Gene Name:

  NSMCE4A

• Gene ID:

  54780

• UniProt:

  Q9NXX6

• Chromosomal Location:

  Nucleus. Chromosome, telomere

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) . Is involved in positive regulation of response to DNA damage stimulus.

• Molecular Weight:

  44301

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NSE4A Antibody (N-term) [APR06212G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=54780

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NXX6