Phospho-p16-INK4A (S140) Antibody [APR05135G]

• Background:

  Tissue Location: Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific

• Synonyms:

  Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, Cyclin-dependent kinase 4 inhibitor A, CDK4I, Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A, CDKN2A, CDKN2, MTS1

• Gene Name:

  HGNC:1787

• Gene ID:

  1029

• UniProt:

  P42771

• Chromosomal Location:

  Cytoplasm. Nucleus

• Applications:

  WB, IHC-P

• Dilution:

  WB--1:1000 IHC-P--1:100~500

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

• Molecular Weight:

  16533

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-p16-INK4A (S140) Antibody [APR05135G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1029

• Uniprot URL:

  https://www.uniprot.org/uniprot/P42771