SAE1 (AOS1) Antibody (C-term) [APR05045G]

• Background:

  Tissue Location: Expression level increases during S phase and drops in G2 phase (at protein level) .

• Synonyms:

  SUMO-activating enzyme subunit 1, Ubiquitin-like 1-activating enzyme E1A, SUMO-activating enzyme subunit 1, N-terminally processed, SAE1, AOS1, SUA1, UBLE1A

• Gene Name:

  SAE1

• Gene ID:

  10055

• UniProt:

  Q9UBE0

• Chromosomal Location:

  Nucleus.

• Applications:

  WB, IHC-P

• Dilution:

  WB--1:1000 IHC-P--1:100~500

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

• Function:

  The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

• Molecular Weight:

  38450

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SAE1 (AOS1) Antibody (C-term) [APR05045G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=10055

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UBE0