Mouse p27Kip1 Antibody (C-term T197) [APR04544G]

• Synonyms:

  Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, Cdkn1b

• Gene Name:

  Cdkn1b

• Gene ID:

  12576

• UniProt:

  P46414

• Chromosomal Location:

  Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-197, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89 (By similarity) Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (PubMed:20228253) . {ECO:0000250, ECO:0000269|PubMed:20228253}

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  8033213129725558033213

• Molecular Weight:

  22193

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse p27Kip1 Antibody (C-term T197) [APR04544G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=12576

• Uniprot URL:

  https://www.uniprot.org/uniprot/P46414