BCAS3 Antibody (C-term) [APR03955G]

• Background:

  Tissue Location: Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells Expressed in blood islands and nascent blood vessels derived from differentiated ES cells into embryoid bodies (BD) . Expressed in endothelial cells. Not detected in brain. Expressed in brain tumors (at protein level) . Expressed in brain. Highly expressed in breast cancers and in glioma cell lines.

• Synonyms:

  Breast carcinoma-amplified sequence 3 {ECO:0000312|HGNC:HGNC:14347, ECO:0000312|MIM:607470}, GAOB1, BCAS3 {ECO:0000312|HGNC:HGNC:14347, ECO:0000312|MIM:607470}

• Gene Name:

  BCAS3 {ECO:0000312|HGNC:HGNC:14347, ECO:0000312|MIM:607470}

• Gene ID:

  54828

• UniProt:

  Q9H6U6

• Chromosomal Location:

  Nucleus. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8CCN5}. Preautophagosomal structure. Note=Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity) Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712) . {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  3349971233499712

• Molecular Weight:

  101237

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BCAS3 Antibody (C-term) [APR03955G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=54828

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9H6U6