TNFAIP8L3 Antibody (Center) [APR03623G]

• Background:

  Tissue Location: Widely expressed (at protein level) (PubMed:25479791) . Highly expressed in most carcinoma cell lines (PubMed:25479791, PubMed:25242044) .

• Synonyms:

  Tumor necrosis factor alpha-induced protein 8-like protein 3, TNF alpha-induced protein 8-like protein 3, TNFAIP8-like protein 3, TNFAIP8L3

• Gene Name:

  TNFAIP8L3

• Gene ID:

  388121

• UniProt:

  Q5GJ75

• Chromosomal Location:

  Cytoplasm. Cell membrane {ECO:0000250|UniProtKB:Q3TBL6}. Note=On PDGF activation, translocates from cytoplasm to plasma membrane {ECO:0000250|UniProtKB:Q3TBL6}

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.

• Molecular Weight:

  32659

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TNFAIP8L3 Antibody (Center) [APR03623G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=388121

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q5GJ75