STMN1 Antibody (C-Term) [APR13580G]

• Background:

  Tissue Location: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

• Synonyms:

  Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17, STMN1, C1orf215, LAP18, OP18

• Gene Name:

  STMN1

• Gene ID:

  3925

• UniProt:

  P16949

• Chromosomal Location:

  Cytoplasm, cytoskeleton.

• Applications:

  WB, FC

• Dilution:

  FC--1:25 WB--1:2000

• Function:

  Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity) .

• Molecular Weight:

  17303

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STMN1 Antibody (C-Term) [APR13580G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=3925

• Uniprot URL:

  https://www.uniprot.org/uniprot/P16949