KCTD11 Antibody (N-Term) [AMM06173G]

• Background:

  Tissue Location: Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma.

• Synonyms:

  BTB/POZ domain-containing protein KCTD11, KCTD11, C17orf36, REN

• Gene Name:

  KCTD11

• Gene ID:

  147040

• UniProt:

  Q693B1

• Applications:

  WB, IHC-P

• Dilution:

  WB--1:1000-1:2000 IHC-P--1:100~500

• Function:

  Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin- dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB) . Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down- regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.

• Molecular Weight:

  25887

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KCTD11 Antibody (N-Term) [AMM06173G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=147040

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q693B1