Mouse Ddr2 Antibody (Center) [AMM06427G]

• Background:

  Tissue Location: Widely expressed. Detected in lung, ovary, skin and in testis Leydig cells (at protein level) . Widely expressed. Detected at high levels in heart, lung, skeletal muscle, central nervous system (CNS) and kidney, and at lower levels in brain and testis. Detected in chondrocytes in tibia growth plates of young mice

• Synonyms:

  Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, Ddr2, Ntrkr3, Tkt, Tyro10

• Gene Name:

  Ddr2

• Gene ID:

  18214

• UniProt:

  Q62371

• Chromosomal Location:

  Cell membrane; Single-pass type I membrane protein

• Applications:

  WB

• Dilution:

  WB--1:1000

• Function:

  Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up- regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

• Molecular Weight:

  96482

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Ddr2 Antibody (Center) [AMM06427G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=18214

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q62371