Ddr2 (NM_022563) Mouse Recombinant Protein

• Background:

  Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AW495251; Ntrkr3; tyro10

• Gene ID:

  18214

• UniProt:

  Q62371

• Accession Number mRNA:

  NM_022563

• Chromosomal Location:

  1 76.84 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  96.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ddr2

• Species:

  Mouse

• Protein ID:

  NP_072075

• Overview:

  Purified recombinant protein of Mouse discoidin domain receptor family, member 2 (Ddr2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/18214

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q62371

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_022563

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_072075